Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 16/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 13/20 | 0.43 |
| ▸ | CLK2 | P49760 | 13/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 12/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.43 |
| ▸ | PAK4 | O96013 | 11/20 | 0.43 |
| ▸ | PRKX | P51817 | 11/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 11/20 | 0.43 |
| ▸ | CDK2 | P24941 | 11/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 10/20 | 0.43 |
| ▸ | CDK7 | P50613 | 10/20 | 0.43 |
| ▸ | MELK | Q14680 | 10/20 | 0.43 |
| ▸ | CDK9 | P50750 | 9/20 | 0.43 |
| ▸ | PRKACA | P17612 | 8/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.43 |
| ▸ | GSK3B | P49841 | 7/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27788221 | 0.86 | CDC7 (0.46) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL3673366 | 0.86 | CDC7 (0.44) | CDC7HIPK2CLK2DAPK3CDK5 | |
| Tert-Butyl Formate SCHEMBL27810094 | 0.78 | CDC7 (0.61) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL27788231 | 0.78 | ROCK2 (0.58) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL3669600 | 0.69 | CDC7 (0.52) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL4293896 | 0.67 | CDC7 (0.64) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL3667784 | 0.64 | ROCK2 (0.65) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL3668495 | 0.62 | CDC7 (1.00) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL3672059 | 0.62 | ROCK2 (0.71) | CDC7HIPK2CLK2DAPK3CDK5 | |
| SCHEMBL3666765 | 0.61 | CDC7 (0.81) | CDC7HIPK2CLK2DAPK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101790526-A | 5-heteroaryl substituted indazoles as kinase inhibitors | ABBOTT GMBH & CO KG | 2010-07-28 | — | — | CN | disclosed |