Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.58 |
| ▸ | GSK3B | P49841 | 8/20 | 0.58 |
| ▸ | CLK2 | P49760 | 7/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.58 |
| ▸ | CSNK1G2 | P78368 | 5/20 | 0.58 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.58 |
| ▸ | GSK3A | P49840 | 4/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.58 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.58 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.58 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.58 |
| ▸ | CDC7 | O00311 | 15/20 | 0.52 |
| ▸ | CDK2 | P24941 | 9/20 | 0.52 |
| ▸ | PRKACA | P17612 | 7/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 7/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.52 |
| ▸ | CDK1 | P06493 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667784 | 0.82 | ROCK2 (0.65) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL3672059 | 0.81 | ROCK2 (0.71) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL27788237 | 0.80 | CDC7 (0.53) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL27810081 | 0.80 | CDC7 (0.53) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL27788234 | 0.78 | CDC7 (0.56) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL27810092 | 0.78 | CDC7 (0.44) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL3666082 | 0.77 | ROCK2 (0.66) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL3667253 | 0.74 | ROCK2 (1.00) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL3668369 | 0.72 | ROCK2 (0.75) | ROCK2GSK3BCLK2MAPK1CLK4 | |
| SCHEMBL28124611 | 0.72 | ALDH1A1 (0.38) | MAPK1CDK5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101790526-A | 5-heteroaryl substituted indazoles as kinase inhibitors | ABBOTT GMBH & CO KG | 2010-07-28 | — | — | CN | disclosed |