Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 7/20 | 0.46 |
| ▸ | GART | P22102 | 6/20 | 0.46 |
| ▸ | ATIC | P31939 | 5/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447066 | 0.92 | AKR1B1 (0.53) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27519163 | 0.90 | AKR1B1 (0.51) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL30350193 | 0.90 | AKR1B1 (0.51) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL28205287 | 0.88 | AKR1B1 (0.48) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL30584152 | 0.87 | AKR1B1 (0.47) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27925894 | 0.87 | AKR1B1 (0.47) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27529220 | 0.87 | AKR1B1 (0.47) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27925895 | 0.87 | AKR1B1 (0.46) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27983477 | 0.84 | AKR1B1 (0.49) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL27666711 | 0.83 | TYMS (0.53) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109182352-A | A kind of Senescence of Rice controlling gene, protein and application | 杭州师范大学 | 2019-01-11 | — | — | CN | claimed |
| CN-108976232-A | A kind of synthetic method of Calcium leucovorin | 江苏红豆杉药业有限公司 | 2018-12-11 | — | — | CN | claimed |
| CN-110225755-A | Combination of BRD4 inhibitors and antifolates for treatment of cancer | 分子医学研究中心责任有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-109549948-A | The application of root bark of tree peony polysaccharide, the toothpaste containing root bark of tree peony polysaccharide and preparation method thereof | 河北神顺健康科技有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109456330-A | Folic acid class stable compound and preparation method thereof | 连云港德洋化工有限公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-109105645-A | A kind of monkey grain and preparation method thereof | 江苏省协同医药生物工程有限责任公司 | 2019-01-01 | — | — | CN | disclosed |
| CN-103087971-B | Increase methionine yield | 代谢探索者公司 | 2016-12-28 | — | — | CN | disclosed |
| CN-104114174-A | Anti-tumor activity of reduced folates like methylene-tetrahydrofolate | ISOFOL MEDICAL AB | 2014-10-22 | — | — | CN | disclosed |
| CN-104114173-A | Combinations of tetrahydrofolate and EGFR inhibitors | ISOFOL MEDICAL AB | 2014-10-22 | — | — | CN | disclosed |
| CN-101821401-B | Increasing methionine yield | METABOLIC EXPLORER SA | 2013-10-30 | — | — | CN | disclosed |
| CN-103087971-A | Increasing methionine yield | METABOLIC EXPLORER SA | 2013-05-08 | — | — | CN | disclosed |
| CN-101821401-A | Increasing methionine yield | METABOLIC EXPLORER SA | 2010-09-01 | — | — | CN | disclosed |