Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | TYMS | P04818 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | DHFR | P00374 | 5/20 | 0.38 |
| ▸ | ATIC | P31939 | 3/20 | 0.38 |
| ▸ | GART | P22102 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27519163 | 1.00 | AKR1B1 (0.51) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30447066 | 0.92 | AKR1B1 (0.53) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL27812907 | 0.90 | TYMS (0.62) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL27925895 | 0.85 | AKR1B1 (0.46) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL27925894 | 0.84 | AKR1B1 (0.47) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30584152 | 0.84 | AKR1B1 (0.47) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL28205287 | 0.83 | AKR1B1 (0.48) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL27529220 | 0.83 | AKR1B1 (0.47) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL29575293 | 0.79 | TYMS (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL5683350 | 0.79 | TYMS (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240415837-A1 | PHARMACOLOGIC MODULATION OF 5-FLUOROURACIL BY FOLINIC ACID AND VITAMIN B6 FOR THE TREATMENT OF PATIENTS WITH CARCINOMA | MACHOVER DAVID (FR) | 2024-12-19 | — | — | US | disclosed |
| EP-4419107-A1 | PHARMACOLOGIC MODULATION OF 5-FLUOROURACIL BY FOLINIC ACID AND VITAMIN B6 FOR THE TREATMENT OF PATIENTS WITH CARCINOMA | Machover, David (FR) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023066865-A1 | PHARMACOLOGIC MODULATION OF 5-FLUOROURACIL BY FOLINIC ACID AND VITAMIN B6 FOR THE TREATMENT OF PATIENTS WITH CARCINOMA | MACHOVER DAVID (FR) | 2023-04-27 | — | — | WO | disclosed |