Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22764029 | 0.77 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL12635347 | 0.73 | ALDH1A1 (0.40) | ALDH1A1LMNA | |
| SCHEMBL28195239 | 0.69 | ALDH1A1 (0.35) | ALDH1A1LMNA | |
| SCHEMBL10231043 | 0.69 | ERN1 (0.31) | — | |
| SCHEMBL13363566 | 0.67 | ALDH1A1 (0.54) | ALDH1A1LMNA | |
| SCHEMBL469386 | 0.67 | ALDH1A1 (0.72) | ALDH1A1LMNA | |
| SCHEMBL1747944 | 0.66 | ALDH1A1 (0.56) | ALDH1A1LMNA | |
| SCHEMBL27689981 | 0.66 | ALDH1A1 (0.50) | ALDH1A1LMNA | |
| SCHEMBL28177256 | 0.66 | TP53 (0.33) | ALDH1A1LMNA | |
| SCHEMBL22764290 | 0.66 | TDP1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307475-A | Treatment of lung cancer with a PARP inhibitor in combination with a growth factor inhibitor | BIPAR SCIENCES INC | 2012-01-04 | — | — | CN | disclosed |
| CN-101888777-A | Treatment of cancer with combinations of topoisomerase inhibitors and PARP inhibitors | BIPAR SCIENCES INC | 2010-11-17 | — | — | CN | disclosed |