Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | RARA | P10276 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | MTOR | P42345 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | RARG | P13631 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | TACR2 | P21452 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27643232 | 1.00 | RARB (0.73) | RARBALDH1A1RARAMEN1MAPT | |
| Bicarbonate SCHEMBL27623722 | 0.98 | RARB (0.72) | RARBALDH1A1RARAMEN1MAPT | |
| Acetic Acid SCHEMBL9000257 | 0.95 | RARB (0.71) | RARBALDH1A1RARAMEN1MAPT | |
| Bicarbonate SCHEMBL27623751 | 0.93 | RARB (0.71) | RARBALDH1A1RARAMEN1MAPT | |
| SCHEMBL5599589 | 0.93 | HSD11B1 (0.67) | RARBALDH1A1RARAMEN1MAPT | |
| SCHEMBL5599226 | 0.93 | HSD11B1 (0.67) | RARBALDH1A1RARAMEN1MAPT | |
| SCHEMBL9158137 | 0.93 | HSD11B1 (0.67) | RARBALDH1A1RARAMEN1MAPT | |
| SCHEMBL1533772 | 0.93 | HSD11B1 (0.67) | RARBALDH1A1RARAMEN1MAPT | |
| SCHEMBL4598933 | 0.93 | HSD11B1 (0.67) | RARBALDH1A1RARAMEN1MAPT | |
| SCHEMBL28362102 | 0.93 | HSD11B1 (0.67) | RARBALDH1A1RARAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104136508-A | Process for the production of low stress and optical quality film for use in opto-electronic devices | BAYER MATERIALSCIENCE AG | 2014-11-05 | — | — | CN | disclosed |
| CN-102224010-A | Security feature in security or value documents | BAYER MATERIALSCIENCE AG | 2011-10-19 | — | — | CN | disclosed |
| CN-102196920-A | ID card with laser engraving resistance | BAYER MATERIALSCIENCE AG | 2011-09-21 | — | — | CN | disclosed |
| CN-102164753-A | Use of plastic films in colour laser printing | BAYER MATERIALSCIENCE AG | 2011-08-24 | — | — | CN | disclosed |