Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | RARA | P10276 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27623722 | 0.94 | RARB (0.72) | RARBALDH1A1MEN1RARAMAPT | |
| Bicarbonate SCHEMBL27643232 | 0.93 | RARB (0.73) | RARBALDH1A1MEN1RARAMAPT | |
| Bicarbonate SCHEMBL27817579 | 0.93 | RARB (0.73) | RARBALDH1A1MEN1RARAMAPT | |
| SCHEMBL402463 | 0.92 | HSD11B1 (0.68) | RARBALDH1A1MEN1RARAMAPT | |
| SCHEMBL9158283 | 0.92 | HSD11B1 (0.68) | RARBALDH1A1MEN1RARAMAPT | |
| Boric Acid SCHEMBL29240144 | 0.89 | RARB (0.61) | RARBALDH1A1MEN1RARAMAPT | |
| SCHEMBL28842038 | 0.89 | RARB (0.61) | RARBALDH1A1MEN1RARAMAPT | |
| Bicarbonate SCHEMBL27643185 | 0.88 | FFAR1 (0.62) | RARBALDH1A1MEN1RARAMAPT | |
| Ethyne SCHEMBL28914485 | 0.88 | HSD11B1 (0.64) | RARBALDH1A1MEN1RARAMAPT | |
| Butylbenzyl SCHEMBL27660882 | 0.88 | ALDH1A1 (0.64) | RARBALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108290820-A | Method for recovering aromatic alcohol from melt polymerization and system for recovering same | 沙特基础工业全球技术有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-105189604-B | The production of makrolon with limited metal residue | 沙特基础全球技术有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-107075103-A | The method that makrolon is manufactured using liquid alcohol/ketone mixtures | 沙特基础工业全球技术有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104231254-B | For the method producing polycarbonate compositions | 沙特基础全球技术有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-105473223-A | Heterogeneous catalysts for the transesterification of aromatic alcohols; and methods of making and use thereof | SABIC INNOVATIVE PLASTICS IP BV | 2016-04-06 | — | — | CN | disclosed |
| CN-103003050-B | Apparatus and method for producing products from pigment-containing polymer mixtures | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-24 | — | — | CN | disclosed |
| CN-105189604-A | Production of a polycarbonate with limited metal residuals | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104231254-A | Process for the manufacture of polycarbonate compositions | SABIC INNOVATIVE PLASTICS IP | 2014-12-24 | — | — | CN | disclosed |
| CN-104136508-A | Process for the production of low stress and optical quality film for use in opto-electronic devices | BAYER MATERIALSCIENCE AG | 2014-11-05 | — | — | CN | disclosed |
| CN-103748259-A | A process for multi-layer continuous roll-to-roll coating | BAYER SOUTH EAST ASIA PTE LTD | 2014-04-23 | — | — | CN | disclosed |
| CN-103221229-A | Multilayer decorative film | BAYER IP GMBH | 2013-07-24 | — | — | CN | disclosed |
| CN-103003050-A | Apparatus and method for producing products from pigment-containing polymer mixtures | BAYER MATERIALSCIENCE AG | 2013-03-27 | — | — | CN | disclosed |
| CN-101429277-B | Method for producing polycarbonate by the melt transesterification method | BAYER MATERIALSCIENCE AG | 2013-03-27 | — | — | CN | disclosed |
| CN-102442910-A | Process for preparing diaryl carbonates from dialkyl carbonates | BAYER MATERIALSCIENCE AG | 2012-05-09 | — | — | CN | disclosed |
| CN-102224010-A | Security feature in security or value documents | BAYER MATERIALSCIENCE AG | 2011-10-19 | — | — | CN | disclosed |
| CN-102196920-A | ID card with laser engraving resistance | BAYER MATERIALSCIENCE AG | 2011-09-21 | — | — | CN | disclosed |
| CN-102164753-A | Use of plastic films in colour laser printing | BAYER MATERIALSCIENCE AG | 2011-08-24 | — | — | CN | disclosed |
| CN-1712450-B | Thermally stable polycarbonate compositions | BAYER MATERIALSCIENCE AG | 2010-05-26 | — | — | CN | disclosed |
| CN-101429277-A | Method for producing polycarbonate by the melt transesterification method | BAYER MATERIALSCIENCE AG (DE) | 2009-05-13 | — | — | CN | disclosed |
| CN-1712450-A | Thermally stable polycarbonate compositions | BAYER MATERIALSCIENCE AG (DE) | 2005-12-28 | — | — | CN | disclosed |