Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 11/20 | 0.56 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.56 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.56 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.56 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.56 |
| ▸ | GRM8 | O00222 | 2/20 | 0.56 |
| ▸ | GRM6 | O15303 | 2/20 | 0.56 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL28284774 | 0.95 | GRIK1 (0.61) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL12076452 | 0.93 | GRIK1 (0.58) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL28273297 | 0.93 | GRIK1 (0.58) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL886966 | 0.93 | GRIK1 (0.58) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL886965 | 0.93 | GRIK1 (0.58) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Alpha-Ketoglutaric Acid SCHEMBL4366423 | 0.89 | MAPK1 (0.58) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Alpha-Ketoglutaric Acid SCHEMBL1471943 | 0.89 | MAPK1 (0.58) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL3230 | 0.87 | — | — | |
| Aspartic Acid SCHEMBL996424 | 0.87 | GRIK1 (0.56) | GRIK1GRIK2GRIA4GRIK3GRIK5 | |
| Aspartic Acid SCHEMBL11065189 | 0.87 | GRIK1 (0.56) | GRIK1GRIK2GRIA4GRIK3GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102220186-A | Scale-reducing additive for automatic dishwashing systems | ROHM & HAAS | 2011-10-19 | — | — | CN | claimed |
| CN-102191139-A | Scale-reducing additive for automatic dishwashing systems | ROHM & HAAS | 2011-09-21 | — | — | CN | claimed |
| CN-102191139-B | Scale-reducing additive for automatic dishwashing systems | ROHM & HAAS | 2013-07-17 | — | — | CN | disclosed |
| CN-102220186-A | Scale-reducing additive for automatic dishwashing systems | ROHM & HAAS | 2011-10-19 | — | — | CN | disclosed |
| CN-102191139-A | Scale-reducing additive for automatic dishwashing systems | ROHM & HAAS | 2011-09-21 | — | — | CN | disclosed |