Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 11/20 | 0.58 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.58 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL886965 | 1.00 | GRIK1 (0.58) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL28273297 | 1.00 | GRIK1 (0.58) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL31673497 | 0.94 | — | — | |
| Aspartic Acid SCHEMBL11065189 | 0.94 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL31070222 | 0.94 | — | — | |
| Aspartic Acid SCHEMBL11065185 | 0.94 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL3231 | 0.94 | — | — | |
| D-Aspartate SCHEMBL145539 | 0.94 | — | — | |
| Aspartic Acid SCHEMBL996424 | 0.94 | GRIK1 (0.56) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Aspartic Acid SCHEMBL3230 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3106466-B1 | PEPTIDE, MAGNETIC PEPTIDE AND METHOD FOR DETECTING CELIAC DISEASE | UNIV AUTòNOMA DE BARCELONA (ES) | 2019-04-10 | — | — | EP | disclosed |
| US-10156565-B2 | Peptide, magnetic peptide and method for detecting celiac disease | UNIVERSITAT AUTONOMA DE BARCELONA (ES) | 2018-12-18 | — | — | US | disclosed |
| US-20170153233-A1 | PEPTIDE, MAGNETIC PEPTIDE AND METHOD FOR DETECTING CELIAC DISEASE | UNIVERSITAT AUTONOMA DE BARCELONA (ES) | 2017-06-01 | — | — | US | disclosed |
| EP-3106466-A1 | PEPTIDE, MAGNETIC PEPTIDE AND METHOD FOR DETECTING CELIAC DISEASE | Universitat Autònoma de Barcelona (ES) | 2016-12-21 | — | — | EP | disclosed |
| EP-2131662-B1 | PROCESS OF PRODUCING TOMATO PASTE | UNILEVER NV (NL) | 2012-01-11 | — | — | EP | disclosed |
| EP-2131662-A1 | PROCESS OF PRODUCING TOMATO PASTE | UNILEVER N.V. (NL) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008119618-A1 | PROCESS OF PRODUCING TOMATO PASTE | UNILEVER N.V. (NL) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10156565-B2 | Peptide, magnetic peptide and method for detecting celiac disease | VIP, HAMP, PEPD | GRIK1 3275/4885GRIK2 3543/4885GRM1 3699/4885 |
| US-20170153233-A1 | PEPTIDE, MAGNETIC PEPTIDE AND METHOD FOR DETECTING CELIAC DISEASE | VIP, HAMP, PEPD | GRIK1 3275/4885GRIK2 3543/4885GRM1 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.