Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alpha-Ketoglutaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.58 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.58 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 11/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 5/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 5/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | GRM8 | O00222 | 2/20 | 0.50 |
| ▸ | GRM6 | O15303 | 2/20 | 0.50 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Ketoglutaric Acid SCHEMBL4366423 | 1.00 | MAPK1 (0.58) | MAPK1SLC13A3EGLN1OR51E2GRIK1 | |
| Aspartic Acid SCHEMBL27820838 | 0.89 | GRIK1 (0.56) | EGLN1GRIK1GRIK2GRIA4GRIK3 | |
| Aspartic Acid SCHEMBL28284774 | 0.89 | GRIK1 (0.61) | EGLN1GRIK1GRIK2GRIA4GRIK3 | |
| Alpha-Ketoglutaric Acid SCHEMBL5276805 | 0.88 | MAPK1 (0.54) | MAPK1SLC13A3EGLN1OR51E2GRIK1 | |
| Aspartic Acid SCHEMBL12076452 | 0.87 | GRIK1 (0.58) | EGLN1GRIK1GRIK2GRIA4GRIK3 | |
| Glutamic Acid SCHEMBL5148593 | 0.87 | GRM8 (0.56) | MAPK1SLC13A3EGLN1OR51E2GRIK1 | |
| Glutamic Acid SCHEMBL148727 | 0.83 | GRM8 (0.75) | MAPK1SLC13A3EGLN1OR51E2GRIK1 | |
| D-Glutamate SCHEMBL148726 | 0.83 | GRM8 (0.75) | MAPK1SLC13A3EGLN1OR51E2GRIK1 | |
| Alpha-Ketoglutaric Acid SCHEMBL1471949 | 0.83 | EGLN1 (0.58) | MAPK1SLC13A3EGLN1OR51E2GRIK1 | |
| D-Glutamate SCHEMBL6138602 | 0.83 | GRM8 (0.75) | MAPK1SLC13A3EGLN1OR51E2GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190091300-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2019-03-28 | — | — | US | disclosed |
| US-10159717-B2 | Methods of treating cancer of the central nervous system | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2018-12-25 | — | — | US | disclosed |
| CN-106868066-A | The method for producing the microorganism of O acetylhomoserines and O acetylhomoserines being produced using the microorganism | CJ第制糖株式会社 | 2017-06-20 | — | — | CN | disclosed |
| CN-103797027-B | Variant polypeptide having homoserine acetyltransferase activity and microorganism expressing same | CJ 第制糖株式会社 | 2017-05-17 | — | — | CN | disclosed |
| CN-104911136-A | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism | CJ CHEILJEDANG CORP | 2015-09-16 | — | — | CN | disclosed |
| US-20150216949-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-08-06 | — | — | US | disclosed |
| US-9034319-B2 | Methods of treating cancer of the central nervous system | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-05-19 | — | — | US | disclosed |
| US-20110070218-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2011-03-24 | — | — | US | disclosed |
| US-7767204-B2 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2010-08-03 | — | — | US | disclosed |
| US-20090304661-A1 | Method And Composition For Proctecting Neuronal Tissue From Damage Induced By Elevated Glutamate Levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCEINCE (IL) | 2009-12-10 | — | — | US | disclosed |
| US-20090186358-A1 | Pathway Analysis of Cell Culture Phenotypes and Uses Thereof | WYETH (US) | 2009-07-23 | — | — | US | disclosed |
| US-20080233096-A1 | transaminase, dehydrogenase, decarboxylase, ligase as glutamate modifying enzymes and oxaloacetate, pyruvate, NAD+, NADP+, 2-oxohexanedioic acid, 2-oxo-3-sulfopropionate, 2-oxo-3-sulfinopropionic acid, 2-oxo-3-phenylpropionic acid co-factors to enhance brain to blood efflux | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-25 | — | — | US | disclosed |
| US-20080233099-A1 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-25 | — | — | US | disclosed |
| US-7404951-B2 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-07-29 | — | — | US | disclosed |
| US-20060024284-A1 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-02-02 | — | — | US | disclosed |
| US-20050005324-A1 | Gene promoters isolated from potato and use thereof | DAI ZIYU (US) | 2005-01-06 | — | — | US | disclosed |
| US-20020170095-A1 | Gene promoters isolated from potato and use thereof | BATTELLE MEMORIAL INSTITUTE | 2002-11-14 | — | — | US | disclosed |
| EP-1172439-A1 | THERMOSTABLE ENZYME HAVING AMINOTRANSFERASE ACTIVITY AND GENE ENCODING THE SAME | National Institute of Advanced Industrial Science and Technology (JP) | 2002-01-16 | — | — | EP | disclosed |
| CN-1179792-A | Reagent stabilized by coenzyme reduction system | TRACE SCIENT LTD (AU) | 1998-04-22 | — | — | CN | disclosed |
| US-4235962-A | REAGENTS COMPRISING ASPARATE, ALANINE, 2-OXOGLUTARATE AND REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE | THE DOW CHEMICAL COMPANY (US) | 1980-11-25 | — | — | US | disclosed |