Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | STAT6 | P42226 | 9/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710773 | 0.90 | STAT6 (0.49) | JAK3STAT6JAK2BRD4MAP4K1 | |
| SCHEMBL27844371 | 0.88 | JAK3 (0.54) | JAK3STAT6JAK2BRD4MAP4K1 | |
| SCHEMBL3710772 | 0.86 | JAK3 (0.47) | JAK3STAT6JAK2BRD4MAP4K1 | |
| SCHEMBL1284618 | 0.82 | TBK1 (0.60) | JAK3 | |
| SCHEMBL3709267 | 0.78 | MAP4K1 (0.52) | JAK3STAT6JAK2BRD4MAP4K1 | |
| SCHEMBL3709266 | 0.74 | MAP4K1 (0.54) | JAK3STAT6JAK2BRD4MAP4K1 | |
| SCHEMBL27844369 | 0.74 | STAT6 (0.69) | JAK3STAT6JAK2BRD4AURKA | |
| SCHEMBL1284620 | 0.72 | JAK3 (0.42) | JAK3STAT6JAK2MAP4K1 | |
| SCHEMBL17076534 | 0.71 | SYK (0.73) | — | |
| SCHEMBL15163135 | 0.71 | TBK1 (0.56) | JAK3STAT6JAK2BRD4MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | claimed |
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | disclosed |