Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | STAT6 | P42226 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709266 | 0.89 | MAP4K1 (0.54) | JAK3STAT6JAK2PTK2MAP4K1 | |
| SCHEMBL3710773 | 0.87 | STAT6 (0.49) | JAK3STAT6JAK2MAP4K1BRD4 | |
| SCHEMBL27825342 | 0.86 | JAK3 (0.47) | JAK3STAT6JAK2MAP4K1BRD4 | |
| SCHEMBL1284618 | 0.83 | TBK1 (0.60) | JAK3 | |
| SCHEMBL1284620 | 0.79 | JAK3 (0.42) | JAK3STAT6JAK2PTK2MAP4K1 | |
| SCHEMBL3709267 | 0.77 | MAP4K1 (0.52) | JAK3STAT6JAK2MAP4K1TTK | |
| SCHEMBL15163241 | 0.76 | STAT6 (0.64) | JAK3STAT6JAK2BRD4 | |
| SCHEMBL3790567 | 0.76 | STAT6 (0.65) | JAK3STAT6 | |
| SCHEMBL17076534 | 0.75 | SYK (0.73) | — | |
| SCHEMBL27844371 | 0.75 | JAK3 (0.54) | JAK3STAT6JAK2MAP4K1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |