Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032586 | 0.73 | SIRT2 (0.51) | CTSA | |
| SCHEMBL1034665 | 0.72 | CTSA (0.41) | CTSADYRK1AXDHNPY5RGRM5 | |
| SCHEMBL1029917 | 0.72 | EGFR (0.54) | CTSADYRK1AFYNSLC40A1 | |
| SCHEMBL1074809 | 0.72 | SLC40A1 (0.48) | CTSADYRK1AXDHSLC40A1 | |
| SCHEMBL1034552 | 0.71 | PARP1 (0.48) | DYRK1AXDHFYNPDE4APDE4B | |
| SCHEMBL1029911 | 0.70 | XDH (0.53) | DYRK1AXDHNPY5RGRM5TRPV3 | |
| SCHEMBL1032421 | 0.69 | DHODH (0.58) | DYRK1AXDHPDE4APDE4BPDE4C | |
| SCHEMBL1033797 | 0.68 | XDH (0.46) | DYRK1AXDHGRM5TRPV3CTSS | |
| SCHEMBL17772319 | 0.67 | EGFR (0.48) | — | |
| SCHEMBL1029923 | 0.67 | XDH (0.45) | DYRK1AXDHNPY5RGRM5PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083438-B | The quinoline of conditioning agent and related analogs as silent message regulatory factor | 西特里斯药业公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-102083438-A | Quenolines and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2011-06-01 | — | — | CN | disclosed |