Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.34 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27811377 | 0.77 | ALDH1A1 (0.47) | — | |
| SCHEMBL22643835 | 0.76 | IMPDH2 (0.51) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL27831733 | 0.75 | CYP2D6 (0.34) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL2302160 | 0.71 | SLC6A4 (0.59) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2300563 | 0.67 | IMPDH2 (0.48) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2357362 | 0.67 | IMPDH2 (0.48) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6599646 | 0.65 | IMPDH2 (0.56) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL188007 | 0.65 | IMPDH2 (0.61) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL18412741 | 0.65 | IMPDH2 (0.51) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2305103 | 0.64 | SLC6A4 (0.65) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102099031-A | Substituted indolyl and indazolyl derivatives and their use | HOFFMANN LA ROCHE | 2011-06-15 | — | — | CN | claimed |
| CN-102099031-A | Substituted indolyl and indazolyl derivatives and their use | HOFFMANN LA ROCHE | 2011-06-15 | — | — | CN | disclosed |