Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1955331 | 0.93 | BCL2 (0.52) | BCL2BCL2L1 | |
| SCHEMBL27831837 | 0.92 | HTR1A (0.49) | HRH3HTR1ADRD2HTR2AHRH1 | |
| SCHEMBL27850404 | 0.89 | BCL2 (0.51) | CYP1A2CYP3A4CYP2C9CYP2C19BCL2 | |
| SCHEMBL1957460 | 0.88 | BCL2 (0.53) | BCL2BCL2L1 | |
| SCHEMBL27831767 | 0.86 | KMT2A (0.47) | HRH3CYP2C9CYP2C19HTR1ADRD2 | |
| SCHEMBL1958649 | 0.85 | BCL2 (0.49) | BCL2BCL2L1 | |
| SCHEMBL1960135 | 0.84 | BCL2 (0.57) | BCL2 | |
| SCHEMBL1957509 | 0.82 | BCL2 (0.56) | BCL2 | |
| SCHEMBL28791299 | 0.81 | BCL2 (0.49) | BCL2 | |
| SCHEMBL1956294 | 0.81 | BCL2 (0.54) | BCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |