Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 15/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27832139 | 0.86 | NOTUM (0.41) | ARADAMTS5 | |
| SCHEMBL27811999 | 0.84 | NOTUM (0.41) | HTR2AHTR2CHTR2BARADAMTS5 | |
| SCHEMBL27811988 | 0.82 | SIRT6 (0.51) | HTR2AHTR2CHTR2BAR | |
| SCHEMBL27811989 | 0.79 | ALDH1A1 (0.46) | HTR2AHTR2CHTR2BAR | |
| SCHEMBL735198 | 0.75 | BCL2A1 (0.43) | HTR2AHTR2CHTR2BARADAMTS5 | |
| SCHEMBL27832140 | 0.74 | NOTUM (0.41) | HTR2AHTR2CHTR2BFFAR4 | |
| SCHEMBL2567623 | 0.70 | AR (0.56) | AR | |
| SCHEMBL2793351 | 0.70 | AR (0.56) | AR | |
| SCHEMBL2975255 | 0.70 | AR (0.56) | AR | |
| SCHEMBL2980700 | 0.69 | AR (0.52) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102112451-B | Diazepan and piperazine derivatives modulators of chemokine receptors | HOFFMANN LA ROCHE | 2014-01-22 | — | — | CN | disclosed |
| CN-102112451-A | Diazepan and piperazine derivatives modulators of chemokine receptors | HOFFMANN LA ROCHE | 2011-06-29 | — | — | CN | disclosed |