Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18274512 | 0.85 | ALDH1A1 (0.68) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL2781612 | 0.83 | ALDH1A1 (0.72) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL9168254 | 0.82 | ACHE (0.64) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL11158619 | 0.81 | RPS6KB1 (0.54) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL11464268 | 0.79 | ACHE (0.57) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3008947 | 0.77 | ALDH1A1 (0.54) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL13266569 | 0.77 | ALDH1A1 (0.56) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL11624683 | 0.76 | ACHE (0.59) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL2781927 | 0.76 | ACHE (0.57) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL11154769 | 0.76 | ALDH1A1 (0.68) | ALDH1A1ACHEL3MBTL1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795256-B2 | Thieno-pyridinone derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2010-09-14 | — | — | US | disclosed |
| US-20070078131-A1 | Thieno-pyridinone derivatives as kinase inhibitors | CELLTECH R&D LIMITED (GB) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078131-A1 | Thieno-pyridinone derivatives as kinase inhibitors | MAP3K6, MAP4K2, MAP3K15 | ALDH1A1 2586/4885ACHE 3989/4885L3MBTL1 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.