Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HK1 | P19367 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680563 | 0.76 | MAPK1 (0.51) | RAB9AALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL28020925 | 0.76 | IDO1 (0.48) | IDO1TDO2RAB9AALDH1A1HPGD | |
| SCHEMBL23319557 | 0.75 | MAP4K4 (0.45) | IDO1TDO2IKBKBRAB9AALDH1A1 | |
| SCHEMBL5406796 | 0.74 | CLK4 (0.57) | TDO2MAP4K4GRM5 | |
| SCHEMBL31070756 | 0.73 | CYP2A6 (0.56) | IDO1TDO2IKBKBRAB9AALDH1A1 | |
| SCHEMBL15606489 | 0.73 | CYP2A6 (0.56) | IDO1TDO2IKBKBRAB9AALDH1A1 | |
| SCHEMBL6733049 | 0.73 | DPP4 (0.46) | IDO1TDO2RAB9AALDH1A1HPGD | |
| SCHEMBL27440988 | 0.72 | RAB9A (0.50) | IDO1TDO2IKBKBRAB9AALDH1A1 | |
| SCHEMBL980758 | 0.71 | CSNK1A1 (0.62) | IDO1IKBKBRAB9AALDH1A1HPGD | |
| SCHEMBL3855124 | 0.71 | IDO1 (0.48) | IDO1TDO2IKBKBRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102131806-A | Triazolopyridine compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2011-07-20 | — | — | CN | disclosed |
| CN-102131805-A | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2011-07-20 | — | — | CN | disclosed |