Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HK1 | P19367 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12100759 | 0.81 | MAP4K4 (0.46) | MAP4K4ADORA2ANOS3NOS2 | |
| SCHEMBL11901043 | 0.79 | MAP4K4 (0.48) | MAP4K4KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11902083 | 0.79 | MAP4K4 (0.56) | MAP4K4RAB9ANPC1ADORA2AADORA1 | |
| SCHEMBL17555726 | 0.79 | FYN (0.49) | MAP4K4KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1165179 | 0.77 | GSK3B (0.47) | MAP4K4ALDH1A1LMNAIKBKBMAPT | |
| SCHEMBL4938505 | 0.76 | DYRK1A (0.54) | MAP4K4KDM4ERXFP1RAB9AMAPT | |
| SCHEMBL27834016 | 0.75 | IDO1 (0.47) | MAP4K4KDM4ESMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL19721378 | 0.74 | KMT2A (0.47) | MAP4K4KDM4ESMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL3357542 | 0.74 | IDO1 (0.42) | SMN1; SMN2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL27440988 | 0.73 | RAB9A (0.50) | KDM4EALDH1A1HPGDIKBKBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11897882-B2 | Tricyclic crbn ligands and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2024-02-13 | — | — | US | disclosed |
| EP-3817748-A1 | TRICYCLIC CRBN LIGANDS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2021-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11897882-B2 | Tricyclic crbn ligands and uses thereof | CRBN, CRKL, CUL4A | MAP4K4 1845/4885KDM4E 2339/4885SMN1; SMN2 1201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.