Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL28222624 | 1.00 | — | — | |
| Phosphoric Acid SCHEMBL17938394 | 1.00 | CA2 (0.50) | CA2SLC34A1FDPSBLMTDP1 | |
| Phosphoric Acid SCHEMBL1368110 | 1.00 | CA2 (0.50) | CA2SLC34A1FDPSBLMTDP1 | |
| Phosphoric Acid SCHEMBL29117516 | 1.00 | CA2 (0.50) | CA2SLC34A1FDPSBLMTDP1 | |
| Phosphoric Acid SCHEMBL16927155 | 1.00 | — | — | |
| Phosphoric Acid SCHEMBL715759 | 1.00 | CA2 (0.50) | CA2SLC34A1FDPSBLMTDP1 | |
| Phosphoric Acid SCHEMBL34171 | 1.00 | — | — | |
| Phosphoric Acid SCHEMBL29188538 | 1.00 | — | — | |
| Phosphoric Acid SCHEMBL29188543 | 1.00 | CA2 (0.50) | CA2SLC34A1FDPSBLMTDP1 | |
| Phosphoric Acid SCHEMBL4193412 | 1.00 | CA2 (0.50) | CA2SLC34A1FDPSBLMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746338-B2 | Recombinant polymerases for improved single molecule sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-10975362-B2 | Recombinant polymerases for improved single molecule sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190249153-A1 | RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING | PACIFIC BIOSCIENCES CALIFORNIA INC (US) | 2019-08-15 | — | — | US | disclosed |
| US-10167455-B2 | Recombinant polymerases for improved single molecule sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170327801-A1 | RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING | PACIFIC BIOSCIENCES CALIFORNIA INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-9719073-B2 | Recombinant polymerases for improved single molecule sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| EP-2942404-B1 | GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160177384-A1 | SEQUENCING SYSTEMS WITH TWO SLOW-STEP POLYMERASE ENZYMES | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2016-06-23 | — | — | US | disclosed |
| US-9279155-B2 | Step-wise nucleic acid sequencing with catalytic and non-catalytic metals | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| EP-2942404-A1 | GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING | Pacific Biosciences of California, Inc. (US) | 2015-11-11 | — | — | EP | disclosed |
| WO-2011040971-A9 | GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-08-04 | — | — | WO | disclosed |
| US-20110189659-A1 | Generation of modified polymerases for improved accuracy in single molecule sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2011040971-A2 | GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
| EP-2274446-A2 | TWO SLOW-STEP POLYMERASE ENZYME SYSTEMS AND METHODS | Pacific Biosciences of California, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-2271751-A2 | GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING | Pacific Biosciences of California, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| US-20100112645-A1 | Generation of modified polymerases for improved accuracy in single molecule sequencing | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100047802-A1 | NUCLEIC ACID SYNTHESIS COMPOSITIONS AND METHODS AND SYSTEMS FOR USING SAME | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| WO-2009145820-A2 | GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009145828-A2 | TWO SLOW-STEP POLYMERASE ENZYME SYSTEMS AND METHODS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2009-12-03 | — | — | WO | disclosed |
| US-20090286245-A1 | TWO SLOW-STEP POLYMERASE ENZYME SYSTEMS AND METHODS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2009-11-19 | — | — | US | disclosed |