Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070060 | 0.82 | BACE1 (0.55) | BACE1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL30976616 | 0.78 | BACE1 (0.50) | BACE1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL27834830 | 0.77 | ALDH1A1 (0.56) | BACE1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL1599503 | 0.77 | PIK3CD (0.37) | BACE1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL12638759 | 0.77 | NCK1 (0.58) | BACE1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL28405112 | 0.74 | DYRK1A (0.52) | BACE1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL3455999 | 0.74 | BACE1 (1.00) | BACE1PLAUNCF1 | |
| SCHEMBL12638533 | 0.73 | CYP1A2 (0.44) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4889091 | 0.73 | BACE1 (0.63) | BACE1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL1164735 | 0.71 | NCF1 (0.65) | BACE1MAPTKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102325766-A | Heteroaryl substituted pyridazinone derivatives | HOFFMANN LA ROCHE | 2012-01-18 | — | — | CN | disclosed |