Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP5 | P51878 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580680 | 0.82 | ALDH1A1 (0.59) | KCNH2LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27815223 | 0.78 | HTR6 (0.41) | HRH4 | |
| SCHEMBL1579369 | 0.77 | MAPT (0.40) | LMNAMAPTALDH1A1HRH4MAPK1 | |
| SCHEMBL27729958 | 0.77 | MAPT (0.58) | LMNAMAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL27809069 | 0.76 | GRIN2D (0.44) | — | |
| SCHEMBL27829476 | 0.76 | CKS1B (0.35) | ALDH1A1KDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL27714032 | 0.74 | MAPT (0.64) | LMNAMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL31396262 | 0.74 | ALDH1A1 (0.42) | KCNH2LMNAMAPTALDH1A1 | |
| SCHEMBL28785119 | 0.74 | MAPT (0.46) | LMNAMAPTALDH1A1MAPK1KMT2A | |
| SCHEMBL28024438 | 0.73 | MAPT (0.51) | LMNAMAPTALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102137856-A | 2, 4' -bipyridine compounds as protein kinase D inhibitors useful for the treatment of IA heart failure and cancer | NOVARTIS AG | 2011-07-27 | — | — | CN | disclosed |