Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | KCNT1 | Q5JUK3 | 4/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | FGR | P09769 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30893561 | 0.89 | RET (0.40) | RETKDM4EKMT2APSMB8PSMB9 | |
| SCHEMBL4072006 | 0.79 | PSMB8 (0.45) | RETKDM4EPSMB8PSMB9PSMB5 | |
| SCHEMBL28158441 | 0.77 | SRC (0.34) | RETPSMB8PSMB9PSMB5KCNT1 | |
| SCHEMBL28157869 | 0.76 | SRC (0.34) | RETPSMB8PSMB9PSMB5KCNT1 | |
| SCHEMBL19091627 | 0.75 | KDM4E (0.40) | RETKDM4EKMT2APSMB8PSMB9 | |
| SCHEMBL15283440 | 0.75 | NPC1 (0.41) | RETKDM4EKMT2ACYP1A2HCK | |
| SCHEMBL30281173 | 0.75 | RET (0.42) | RET | |
| SCHEMBL29221245 | 0.73 | RET (0.37) | RETHCKKDR | |
| SCHEMBL24007926 | 0.73 | RET (0.40) | RETKDM4EKMT2ACYP1A2HCK | |
| SCHEMBL6887721 | 0.73 | MAP3K12 (0.40) | RETKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102159548-A | Amide compounds useful in therapy | PFIZER LTD | 2011-08-17 | — | — | CN | claimed |
| CN-102159548-A | Amide compounds useful in therapy | PFIZER LTD | 2011-08-17 | — | — | CN | disclosed |