Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670839 | 0.83 | ALDH1A1 (0.44) | LMNAAPAF1POLBKCNJ6KCNJ3 | |
| SCHEMBL9793957 | 0.81 | KCNJ6 (0.38) | LMNAAPAF1POLBKCNJ6KCNJ3 | |
| Hydrochloric Acid SCHEMBL9793971 | 0.81 | ALDH1A1 (0.42) | LMNAAPAF1POLBKCNJ6KCNJ3 | |
| SCHEMBL24799293 | 0.80 | BRD4 (0.53) | LMNAALDH1A1HPGD | |
| SCHEMBL29221245 | 0.80 | RET (0.37) | RETAURKACSF1RLTKCSNK1A1 | |
| SCHEMBL15357765 | 0.79 | BRD4 (0.48) | KCNJ6KCNJ3KCNJ5MAPTALDH1A1 | |
| SCHEMBL12879029 | 0.79 | ALDH1A1 (0.40) | LMNAPOLBKCNJ6KCNJ3KCNJ5 | |
| SCHEMBL23469277 | 0.77 | LMNA (0.34) | LMNAAPAF1POLBKCNJ6KCNJ3 | |
| SCHEMBL15472485 | 0.77 | RET (0.49) | RETAURKACSF1RLTKCSNK1A1 | |
| SCHEMBL28976929 | 0.77 | RET (0.41) | RETAURKACDK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143195-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |