Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | NQO1 | P15559 | 5/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.35 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GNG2 | P59768 | 1/20 | 0.33 |
| ▸ | GNB1 | P62873 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28199787 | 0.93 | KIF11 (0.44) | KIF11NQO1CHRNEDRD3CDK4 | |
| SCHEMBL27525331 | 0.79 | KIF11 (0.43) | KIF11NQO1DRD3CDK4CCND1 | |
| SCHEMBL27584193 | 0.79 | GNG2 (0.47) | KIF11NQO1DRD3CDK4CCND1 | |
| Piperazine SCHEMBL28163406 | 0.76 | KIF11 (0.46) | KIF11NQO1PNMTCDK4CCND1 | |
| Piperazine SCHEMBL27338022 | 0.76 | KIF11 (0.46) | KIF11NQO1PNMTCDK4CCND1 | |
| Piperazine SCHEMBL28190051 | 0.75 | KIF11 (0.45) | KIF11NQO1PNMTCDK4CCND1 | |
| Piperazine SCHEMBL27837264 | 0.75 | KIF11 (0.45) | KIF11NQO1PNMTCDK4CCND1 | |
| SCHEMBL28815383 | 0.74 | KIF11 (0.39) | KIF11NQO1DRD3CDK4CCND1 | |
| Anthracene SCHEMBL28161518 | 0.74 | GNG2 (0.43) | KIF11NQO1DRD3CDK4CCND1 | |
| SCHEMBL30662035 | 0.73 | BCL2L1 (0.48) | KIF11NQO1PNMTDRD3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102361875-B | 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity | ACTELION PHARMACEUTICALS LTD | 2014-08-20 | — | — | CN | disclosed |
| CN-102361875-A | 2-hydroxyethyl-1h-quinolin-2-one derivatives and their azaisosteric analogues with antibacterial activity | ACTELION PHARMACEUTICALS LTD | 2012-02-22 | — | — | CN | disclosed |