Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.59 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | IL1RN | P18510 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606413 | 0.86 | HDAC2 (0.60) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3135135 | 0.84 | HTR6 (0.60) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL15946029 | 0.83 | HDAC2 (0.64) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL894613 | 0.83 | POLB (0.82) | HDAC2HDAC8HDAC6POLBPFKFB3 | |
| SCHEMBL3127728 | 0.81 | HDAC2 (0.56) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL10386045 | 0.81 | POLB (0.64) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL2941161 | 0.81 | CA12 (0.69) | HDAC2HDAC8HDAC6POLBPFKFB3 | |
| SCHEMBL30493181 | 0.81 | ATIC (0.71) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL10386046 | 0.81 | ATIC (0.71) | HDAC2HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL27180159 | 0.79 | MAPT (0.76) | HDAC2HDAC8HDAC6POLBPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102197023-B | Compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC. (US) | 2015-12-16 | — | — | CN | disclosed |
| CN-102197023-A | Compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2011-09-21 | — | — | CN | disclosed |