Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 8/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381120 | 0.88 | ACACB (0.50) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL6451989 | 0.84 | DRD2 (0.49) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL10209101 | 0.82 | EPHX1 (0.54) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL228180 | 0.82 | EPHX1 (0.50) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL881033 | 0.81 | ACACB (0.50) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL60318 | 0.81 | EPHX1 (0.56) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL508535 | 0.81 | ACACB (0.46) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL6647123 | 0.80 | EPHX1 (0.48) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL3942686 | 0.79 | KMT2A (0.56) | ACACBDRD2EPHX1ACACAKMT2A | |
| SCHEMBL3816616 | 0.79 | KMT2A (0.56) | ACACBDRD2EPHX1ACACAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104262267-B9 | PGI2 receptor modulators for the treatment of prostacyclin (PGI2) receptor-related disorders | 艾尼纳制药公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-104262267-A | Modulators Of The Prostacyclin (pgi2) Receptor Useful For The Treatment Of Disorders Related Thereto | ARENA PHARM INC | 2015-01-07 | — | — | CN | disclosed |
| CN-102036659-B | PGI2 receptor modulators for the treatment of prostacyclin receptor-related disorders | ARENA PHARM INC | 2014-09-17 | — | — | CN | disclosed |
| CN-103483226-A | Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto | ARENA PHARM INC | 2014-01-01 | — | — | CN | disclosed |
| CN-102036659-A | PGI2 receptor modulators for the treatment of prostacyclin receptor-related disorders | ARENA PHARM INC | 2011-04-27 | — | — | CN | disclosed |