Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 15/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312563 | 0.76 | RIPK1 (0.45) | RIPK1HRH4HRH3CCNE1CDK2 | |
| SCHEMBL1311905 | 0.76 | SMN1; SMN2 (0.50) | RIPK1 | |
| SCHEMBL27844795 | 0.74 | RIPK1 (0.64) | RIPK1 | |
| SCHEMBL25781276 | 0.73 | RIPK1 (0.50) | RIPK1RET | |
| SCHEMBL15048557 | 0.72 | PLA2G10 (0.51) | RETGSK3B | |
| SCHEMBL1780415 | 0.71 | RIPK1 (0.50) | RIPK1RETHRH4HRH3 | |
| SCHEMBL1647417 | 0.70 | RIPK1 (0.60) | RIPK1HRH4HRH3 | |
| SCHEMBL29994379 | 0.70 | RIPK1 (0.60) | RIPK1HRH4HRH3 | |
| SCHEMBL1311192 | 0.69 | KDM4E (0.45) | KDR | |
| SCHEMBL1311887 | 0.69 | MMP2 (0.52) | KDRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102224142-A | Having a 5-HT2BNovel pyrazole-3-carboxamide derivatives having receptor antagonistic activity | RAQUALIA PHARMA INC | 2011-10-19 | — | — | CN | disclosed |