Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393095 | 0.87 | THRB (0.59) | TDP1THRBKMT2AAPEX1 | |
| Propanol SCHEMBL27824438 | 0.86 | THRB (0.47) | TDP1THRBSOAT1APEX1 | |
| Bromide SCHEMBL27743787 | 0.85 | THRB (0.57) | TDP1THRBKMT2AAPEX1 | |
| Bromomethane SCHEMBL209152 | 0.83 | THRB (0.55) | TDP1THRBKMT2AAPEX1 | |
| SCHEMBL27848743 | 0.80 | TSHR (0.53) | TDP1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL1701331 | 0.76 | THRB (0.47) | TDP1THRBSOAT1APEX1 | |
| SCHEMBL28802252 | 0.73 | MTTP (0.44) | SOAT1APEX1 | |
| SCHEMBL5990939 | 0.73 | APEX1 (0.73) | TDP1CES2CES1SOAT1MEN1 | |
| SCHEMBL6060800 | 0.73 | PDK2 (0.40) | TDP1CES1MEN1KMT2ACYP2C9 | |
| SCHEMBL6060780 | 0.73 | PDK2 (0.40) | TDP1CES1MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104203918-B | Novel polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the beta2 adrenergic receptor. | 阿尔米雷尔有限公司 | 2017-01-18 | — | — | CN | claimed |
| CN-104203918-A | Novel polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the beta2 adrenergic receptor. | ALMIRALL SA | 2014-12-10 | — | — | CN | claimed |
| CN-101679269-B | Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one as agonist of the beta 2 adrenergic receptor | ALMIRALL LAB | 2013-02-13 | — | — | CN | claimed |
| CN-104203918-B | Novel polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the beta2 adrenergic receptor. | 阿尔米雷尔有限公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-103649089-B | Pyrrolotriazinones as PI3K inhibitors | 阿尔米雷尔有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-102762570-B | pyrazole derivatives as JAK inhibitors | ALMIRALL, S.A. (ES) | 2015-11-25 | — | — | CN | disclosed |
| CN-104854108-A | Pyrrolotriazinone derivatives as pi3k inhibitors | ALMIRALL SA | 2015-08-19 | — | — | CN | disclosed |
| CN-104394852-A | Novel dosage forms and formulations of abediterol | ALMIRALL SA | 2015-03-04 | — | — | CN | disclosed |
| CN-104203918-A | Novel polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the beta2 adrenergic receptor. | ALMIRALL SA | 2014-12-10 | — | — | CN | disclosed |
| CN-103649089-A | Pyrrolotriazinones as PI3K inhibitors | ALMIRALL SA | 2014-03-19 | — | — | CN | disclosed |
| CN-102015680-B | New substituted indolin-2-one derivatives and use thereof as p38 mitogen-activated kinase inhibitors | ALMIRALL SA | 2013-11-20 | — | — | CN | disclosed |
| CN-102325530-A | 5- (2- { [6- (2, 2-difluoro-2-phenylethoxy) hexyl ] amino } -1-hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one for the treatment of lung function | ALMIRALL SA | 2012-01-18 | — | — | CN | disclosed |
| CN-102317264-A | 5- (2- { [6- (2, 2-difluoro-2-phenylethoxy) hexyl ] amino } -1-hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one and its use in the treatment of lung diseases | ALMIRALL SA | 2012-01-11 | — | — | CN | disclosed |
| CN-102026972-A | New substituted spiro[cycloalkyl-1,3'-indol]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors | ALMIRALL SA | 2011-04-20 | — | — | CN | disclosed |
| CN-102015680-A | New substituted indolin-2-one derivatives and their use as p38 mitogen-activated kinase inhibitors | ALMIRALL SA | 2011-04-13 | — | — | CN | disclosed |
| CN-101939291-A | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the beta2 adrenergic receptor | AMIRALL S A | 2011-01-05 | — | — | CN | disclosed |
| CN-101679417-A | New 4,8-diphenyl-polyazanaphthalene derivatives | ALMIRALL LAB | 2010-03-24 | — | — | CN | disclosed |
| CN-101522631-A | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the ss2 adrenergic receptor | ALMIRALL LAB (ES) | 2009-09-02 | — | — | CN | disclosed |
| CN-101268064-A | Pyrazine derivatives useful as adenosine receptor antagonists | ALMIRALL LAB (ES) | 2008-09-17 | — | — | CN | disclosed |
| CN-101218203-A | Derivatives of 4-(2-amino-1-hydroxyethyl) phenol as agonists of the ss2 adrenergic receptor | ALMIRALL PRODESFARMA SA (ES) | 2008-07-09 | — | — | CN | disclosed |