Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27930580 | 0.83 | OPRM1 (0.39) | ALDH1A1OPRM1OPRD1SMN1; SMN2HPGD | |
| SCHEMBL27868888 | 0.83 | OPRM1 (0.41) | ALDH1A1HDAC1OPRM1OPRD1MAPK1 | |
| SCHEMBL27851848 | 0.82 | MAPT (0.39) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL349353 | 0.79 | HDAC1 (0.42) | ALDH1A1HDAC1OPRM1LMNAMAPT | |
| SCHEMBL1510 | 0.75 | OPRM1 (0.58) | OPRM1OPRD1 | |
| SCHEMBL14712065 | 0.75 | HRH3 (0.45) | ALDH1A1HDAC1MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL3052103 | 0.73 | HDAC1 (0.47) | ALDH1A1HDAC1LMNAMAPTMAPK1 | |
| SCHEMBL3054538 | 0.73 | HDAC1 (0.50) | ALDH1A1HDAC1LMNAMAPTMAPK1 | |
| SCHEMBL23588019 | 0.73 | SLC18A3 (0.43) | ALDH1A1HDAC1SMN1; SMN2HDAC3HDAC7 | |
| SCHEMBL15348333 | 0.72 | HDAC1 (0.39) | ALDH1A1HDAC1LMNASMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103347510-A | Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis | AMIRA PHARMACEUTICALS INC | 2013-10-09 | — | — | CN | disclosed |
| CN-102770415-A | Polycyclic compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS INC | 2012-11-07 | — | — | CN | disclosed |
| CN-102666504-A | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS INC | 2012-09-12 | — | — | CN | disclosed |
| CN-102656168-A | Polycyclic compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS INC | 2012-09-05 | — | — | CN | disclosed |
| CN-102639515-A | Compounds as lysophosphatidic acid receptor antagonists | AMIRA PHARMACEUTICALS INC | 2012-08-15 | — | — | CN | disclosed |
| CN-102459204-A | Polycyclic antagonists of lysophosphatidic acid receptors | AMIRA PHARMACEUTICALS INC | 2012-05-16 | — | — | CN | disclosed |