Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 4/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Galactitol SCHEMBL11516787 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL27259380 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL8671937 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL28980943 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL5565935 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL232913 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL11519008 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL9654601 | 0.94 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL8145945 | 0.90 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL23673406 | 0.90 | LMNA (0.85) | LMNAL3MBTL1TDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182963-B1 | HERBAL COMPOSITION ON THE BASIS OF EXTRACTS OF FOENICULUM VULGARE, MURRAYA KOENIGII AND TRIPHALA | DELHI INST OF PHARMACEUTICAL SCIENCES AND RES DIPSAR (IN) | 2013-08-14 | — | — | EP | disclosed |
| EP-2182963-A2 | HERBAL COMPOSITION ON THE BASIS OF EXTRACTS OF FOENICULUM VULGARE, MURRAYA KOENIGII AND TRIPHALA | Delhi Institute Of Pharmaceutical Sciences And Research (DIPSAR) (IN) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009010835-A2 | HERBAL COMPOSITION ON THE BASIS OF EXTRACTS OF FOENICULUM VULGARE, MURRAYA KOENIGII AND TRIPHALA | DELHI INSTITUTE OF PHARMACEUTICAL SCIENCE AND RESEARCH (DIPSAR) (IN) | 2009-01-22 | — | — | WO | disclosed |
| WO-2008104856-A2 | A SYNERGISTIC HERBAL OPHTHALMIC FORMULATION FOR LOWERING THE INTRA OCULAR PRESSURE IN CASE OF GLAUCOMA | DELHI INSTITUTE OF PHARMACEUTICAL SCIENCES AND RESEARCH (DIPSAR) (IN) | 2008-09-04 | — | — | WO | disclosed |