Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.44 |
| ▸ | SCN4A | P35499 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11890402 | 0.85 | GAA (0.52) | GAAALDH1A1MAPTGABRA1GABRB1 | |
| SCHEMBL9967704 | 0.81 | KDM1A (0.56) | KDM1AGAAALDH1A1MAPT | |
| SCHEMBL12356963 | 0.81 | MAPT (0.48) | GAAALDH1A1MAPTGCGR | |
| SCHEMBL17034855 | 0.81 | GAA (0.40) | KDM1AGAAALDH1A1PTGER1MAPT | |
| SCHEMBL325648 | 0.80 | SCN4A (0.60) | KDM1AGAAALDH1A1PTGER1SCN4A | |
| SCHEMBL11334122 | 0.79 | HPGD (0.43) | GAAALDH1A1MAPTTHRBGABRA1 | |
| SCHEMBL13347438 | 0.79 | KDM1A (0.54) | KDM1AGAAALDH1A1PTGER1MAPT | |
| SCHEMBL3727775 | 0.79 | KDM1A (0.54) | KDM1AGAAALDH1A1PTGER1SCN4A | |
| SCHEMBL358044 | 0.79 | KDM1A (0.57) | KDM1AGAAALDH1A1PTGER1SCN4A | |
| SCHEMBL13676822 | 0.79 | KDM1A (0.54) | KDM1AGAAALDH1A1PTGER1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133898-B2 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20100137310-A1 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137310-A1 | RENIN INHIBITORS | REN, ACE, PRSS3 | KDM1A 2916/4885GAA 160/4885ALDH1A1 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.