PRSS3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29945	0.48	7/20
Camostat (SCHEMBL125270)	1.00	5/20
Benzamidine (SCHEMBL61379)	0.94	5/20
SCHEMBL48986	0.57	5/20
SCHEMBL49594	0.67	4/20
SCHEMBL24140	0.50	4/20
SCHEMBL123126	0.48	4/20
SCHEMBL23932	0.48	4/20
SCHEMBL126341	0.46	4/20
SCHEMBL73684	0.44	4/20
Potassium Ion (SCHEMBL123125)	0.43	4/20
Potassium Ion (SCHEMBL126340)	0.41	4/20
SCHEMBL107649	0.71	3/20
SCHEMBL42643	0.64	3/20
SCHEMBL42659	0.64	3/20
Methyl Orange (SCHEMBL19662)	0.62	3/20
SCHEMBL108421	0.62	3/20
SCHEMBL67270	0.62	3/20
SCHEMBL33350	0.61	3/20
SCHEMBL33351	0.61	3/20

Clinical trials — most relevant to PRSS3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis	PHASE1/PHASE2	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus	PHASE2	UNKNOWN
Effects of Topical SLPI on Skin Wounds	PHASE1	COMPLETED
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals	EARLY_PHASE1	RECRUITING
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Effect of Mepolizumab on Severe Eosinophilic Asthma	nan	UNKNOWN
French National Cohort of Patients With PRSS1 Mutations	nan	RECRUITING
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer	nan	UNKNOWN
Germline Mutations in Pancreatic Adenocarcinoma	nan	COMPLETED
Angiotensin-converting Enzyme 2 (ACE2) Expression in Tonsils and Adenoids	nan	WITHDRAWN
The Man Van Project	nan	RECRUITING
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract	nan	COMPLETED
Quebec Pancreas Cancer Study	nan	UNKNOWN
Integrated Proteomic HPLC-ESI-MS Analysis of Salivary Peptides of Preterm Newborns: a Pilot Study	nan	COMPLETED
HSD3B1 Gene Polymorphisms With Outcomes in SARS-CoV-2 Infected Patients	nan	COMPLETED
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity	nan	NOT_YET_RECRUITING
Nasal Epithelial Genetic and Single Cell RNA COVID-19 Study	nan	WITHDRAWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Periodontal Health in Post COVID-19 Patients	nan	UNKNOWN
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery	nan	NOT_YET_RECRUITING
Utilization of CBC-Derived Inflammatory Indices in Assessing Severity and Prognosis of Acute Pancreatitis.	nan	NOT_YET_RECRUITING
Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples	nan	COMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD)	nan	COMPLETED
Feasibility and Effectiveness of Three-day Discharge After Distal Pancreatectomy	nan	NOT_YET_RECRUITING
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin	nan	COMPLETED
Pancreas Volume in Preclinical Type 1 Diabetes	nan	COMPLETED
Genetic Basis of Abdominal Aortic Aneurysm	nan	COMPLETED
MMP Polymorphisms and Acute Coronary Syndromes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRSS3 binder may also engage these)

Protein	Name	Similarity
KLK13	Kallikrein-13	0.965	landscape →
P50342	—	0.962	P50342 →
P27435	—	0.961	P27435 →
Q7RTY5	—	0.960	Q7RTY5 →
P09650	—	0.960	P09650 →
Q8BJR6	—	0.960	Q8BJR6 →
Q00356	—	0.959	Q00356 →
TPSAB1	Tryptase beta-1	0.959	landscape →
O35205	—	0.959	O35205 →
P21845	—	0.959	P21845 →
KLK5	Kallikrein-5	0.958	landscape →
P36376	—	0.958	P36376 →
TPSB2	Tryptase beta-2	0.958	landscape →
P11032	—	0.957	P11032 →
P36369	—	0.956	P36369 →
Q02844	—	0.956	Q02844 →
Q7Z5A4	—	0.956	Q7Z5A4 →
Q3V0Q7	—	0.956	Q3V0Q7 →
P12544	—	0.956	P12544 →
Q5FBW2	—	0.956	Q5FBW2 →
P35034	—	0.956	P35034 →
P00755	—	0.955	P00755 →
P12788	—	0.955	P12788 →
Q76B45	—	0.955	Q76B45 →
P43430	—	0.955	P43430 →
KLK1	Kallikrein-1	0.955	landscape →
P09582	—	0.954	P09582 →
P36368	—	0.954	P36368 →
Q9JHJ7	—	0.954	Q9JHJ7 →
P50340	—	0.954	P50340 →