Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886515 | 0.86 | KDM4E (0.62) | FEN1GABRA5GABRA1ALDH1A1KDM4E | |
| SCHEMBL1064220 | 0.84 | L3MBTL1 (0.64) | GABRA5GABRA1ALDH1A1KDM4ELMNA | |
| SCHEMBL27651859 | 0.75 | CNR2 (0.55) | TP53MAPTCNR2PTGDR2 | |
| SCHEMBL27836563 | 0.75 | P2RX4 (0.61) | FEN1GABRA5ALDH1A1KDM4EHTT | |
| SCHEMBL27854511 | 0.74 | MAPK1 (0.46) | ALDH1A1KDM4ELMNATSHRSMN1; SMN2 | |
| SCHEMBL5117212 | 0.74 | L3MBTL1 (0.52) | GABRA5GABRA1ALDH1A1KDM4ELMNA | |
| SCHEMBL10487820 | 0.74 | APEX1 (0.54) | FEN1GABRA5GABRA1ALDH1A1KDM4E | |
| SCHEMBL1063465 | 0.74 | KDM4E (0.69) | ALDH1A1KDM4ELMNATSHRPKM | |
| SCHEMBL27854540 | 0.73 | L3MBTL1 (0.69) | ALDH1A1KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL4751504 | 0.73 | L3MBTL1 (0.50) | ALDH1A1KDM4ELMNAPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| CN-102015705-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2011-04-13 | — | — | CN | disclosed |