Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290188 | 0.82 | CYP17A1 (0.58) | DGAT1CYP17A1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL10205905 | 0.80 | CYP17A1 (0.54) | DGAT1CYP17A1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL18104279 | 0.80 | CYP17A1 (0.49) | DGAT1CYP17A1CYP3A4CYP1A2KMT2A | |
| SCHEMBL26951480 | 0.77 | CYP17A1 (0.40) | DGAT1CYP17A1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL30760303 | 0.75 | HDAC4 (0.47) | DGAT1CYP17A1CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL7006231 | 0.73 | DGAT1 (0.67) | DGAT1CYP3A4CYP1A2CYP2C19KMT2A | |
| SCHEMBL11262307 | 0.73 | CYP2A6 (0.44) | PRKCZCYP3A4KMT2AMEN1KDM4E | |
| SCHEMBL1257025 | 0.73 | KMT2A (0.47) | PRKCZKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL29521818 | 0.73 | MAPK9 (0.51) | DGAT1PRKCZCYP3A4CYP1A2CYP2C19 | |
| SCHEMBL17841543 | 0.72 | CYP17A1 (0.57) | CYP17A1CYP3A4CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102470127-A | Biaryl compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2012-05-23 | — | — | CN | disclosed |