Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1062667 | 0.89 | KMT2A (0.51) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL13708880 | 0.88 | LMNA (0.53) | LMNANPC1RAB9AGPR35HSD17B10 | |
| SCHEMBL1058238 | 0.86 | LMNA (0.49) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL3426735 | 0.86 | SMO (0.49) | LMNANPC1RAB9AGPR35MEN1 | |
| SCHEMBL1061384 | 0.84 | LMNA (0.47) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL3430411 | 0.84 | SMO (0.42) | LMNANPC1RAB9AGPR35MAPT | |
| SCHEMBL10314563 | 0.84 | LMNA (0.49) | LMNANPC1RAB9AGPR35HSD17B10 | |
| SCHEMBL12962930 | 0.84 | LMNA (0.43) | LMNANPC1RAB9AF2RMEN1 | |
| SCHEMBL1061569 | 0.83 | LMNA (0.46) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL1060628 | 0.81 | SMO (0.54) | LMNANPC1RAB9AHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| CN-102015705-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2011-04-13 | — | — | CN | disclosed |