Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430411 | 0.91 | SMO (0.42) | SMONPC1RAB9AGPR35LMNA | |
| SCHEMBL10314586 | 0.90 | CXCR3 (0.47) | SMOMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1056839 | 0.89 | KMT2A (0.49) | SMONPC1RAB9ALMNAMEN1 | |
| SCHEMBL10004581 | 0.89 | SMO (0.49) | SMONPC1RAB9AGPR35LMNA | |
| SCHEMBL10314590 | 0.88 | SMN1; SMN2 (0.48) | SMONPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL10004576 | 0.87 | LMNA (0.51) | SMONPC1RAB9ALMNA | |
| SCHEMBL1062892 | 0.87 | SMO (0.53) | SMONPC1RAB9AMEN1KMT2A | |
| SCHEMBL10004552 | 0.87 | SMO (0.47) | SMONPC1RAB9AGPR35LMNA | |
| SCHEMBL10005002 | 0.87 | SMO (0.46) | SMONPC1RAB9ALMNAMEN1 | |
| SCHEMBL27854593 | 0.86 | LMNA (0.51) | NPC1RAB9AGPR35LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| CN-102015705-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2011-04-13 | — | — | CN | disclosed |
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |