Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27488745 | 0.81 | AKR1C3 (0.52) | USP2KDM4ETSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL27856477 | 0.80 | USP2 (0.39) | USP2KDM4ETSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL27711381 | 0.80 | KCNH2 (0.41) | — | |
| SCHEMBL27854681 | 0.79 | CYP2C19 (0.39) | USP2KDM4ESMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL27856478 | 0.78 | CYP2C19 (0.39) | USP2KDM4EALDH1A1CYP2C19NPC1 | |
| SCHEMBL27871318 | 0.78 | CYP2C19 (0.39) | USP2KDM4EGAAALDH1A1CYP2C19 | |
| SCHEMBL27854680 | 0.78 | CYP2C19 (0.39) | USP2KDM4EGAATSHRALDH1A1 | |
| SCHEMBL27721481 | 0.77 | TSHR (0.38) | USP2TSHRSMN1; SMN2ALDH1A1CYP2C19 | |
| SCHEMBL27856508 | 0.76 | CYP2C19 (0.37) | USP2KDM4EGAAALDH1A1CYP2C19 | |
| SCHEMBL27691091 | 0.76 | PKM (0.33) | GAATSHRALDH1A1CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102498099-B | HSL inhibitors useful in the treatment of diabetes | HOFFMAN-LA ROCHE LTD. (CH) | 2014-10-29 | — | — | CN | claimed |
| CN-102498099-A | HSL inhibitors useful in the treatment of diabetes | HOFFMANN LA ROCHE | 2012-06-13 | — | — | CN | claimed |
| CN-102498099-B | HSL inhibitors useful in the treatment of diabetes | HOFFMAN-LA ROCHE LTD. (CH) | 2014-10-29 | — | — | CN | disclosed |
| CN-102498099-A | HSL inhibitors useful in the treatment of diabetes | HOFFMANN LA ROCHE | 2012-06-13 | — | — | CN | disclosed |