Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597906 | 0.79 | CXCR4 (0.41) | CXCR4HRH3CHRNB2CHRNA4HSP90AA1 | |
| SCHEMBL805513 | 0.77 | — | — | |
| SCHEMBL11361047 | 0.77 | — | — | |
| SCHEMBL16269257 | 0.77 | TERT (0.41) | CXCR4HRH3CYP2C19CHRM2 | |
| SCHEMBL9053685 | 0.74 | TAAR1 (0.38) | CHRNA7TAAR1HRH3 | |
| SCHEMBL30086100 | 0.73 | KDM4E (0.58) | TAAR1HRH3CYP2D6CYP2C19KDM4E | |
| SCHEMBL229256 | 0.73 | KDM4E (0.58) | TAAR1HRH3CYP2D6CYP2C19KDM4E | |
| SCHEMBL7897858 | 0.73 | CYP2D6 (0.46) | HRH3HSP90AA1CYP2D6CYP2C19TSHR | |
| SCHEMBL1666852 | 0.72 | — | — | |
| SCHEMBL9573114 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102908630-B | 6-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC | 2014-11-19 | — | — | CN | disclosed |
| CN-102766630-B | 6-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC | 2014-05-07 | — | — | CN | disclosed |
| CN-102908630-A | 6-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC | 2013-02-06 | — | — | CN | disclosed |
| CN-102766630-A | 6-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC | 2012-11-07 | — | — | CN | disclosed |
| CN-101410406-B | 6-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC | 2012-06-20 | — | — | CN | disclosed |
| CN-101410406-A | 6-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC (US) | 2009-04-15 | — | — | CN | disclosed |