Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of 1-Methylimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 2/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Methylimidazole SCHEMBL29110563 | 0.98 | NFKB1 (0.60) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL27783724 | 0.90 | NFKB1 (0.60) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL693786 | 0.89 | NFKB1 (0.71) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL27681653 | 0.89 | NFKB1 (0.71) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL4955404 | 0.89 | NFKB1 (0.71) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL14810974 | 0.89 | QPCT (0.54) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL28961953 | 0.87 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL28501189 | 0.87 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL28432809 | 0.87 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLHTT | |
| 1-Methylimidazole SCHEMBL28982070 | 0.87 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102449101-A | Ionic compounds in lithium bromide/water absorption cycle systems | DU PONT | 2012-05-09 | — | — | CN | claimed |
| CN-102449101-A | Ionic compounds in lithium bromide/water absorption cycle systems | DU PONT | 2012-05-09 | — | — | CN | disclosed |