Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO
The experimentally established mechanism targets of 1-Methylimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Methylimidazole SCHEMBL28002048 | 1.00 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28432809 | 1.00 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL14810974 | 0.98 | QPCT (0.54) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28222612 | 0.97 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28961953 | 0.97 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28982070 | 0.97 | QPCT (0.52) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28961948 | 0.95 | QPCT (0.50) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28846320 | 0.95 | QPCT (0.50) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28434510 | 0.94 | NFKB1 (0.46) | QPCTNFKB1HSD17B10QPCTLTBXAS1 | |
| 1-Methylimidazole SCHEMBL28350174 | 0.92 | QPCT (0.47) | QPCTNFKB1HSD17B10QPCTLTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112086564-A | Passivating agent and passivation method thereof and method for preparing semiconductor film | 杭州纤纳光电科技有限公司 | 2020-12-15 | — | — | CN | disclosed |