Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 13/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 4/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.33 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27879615 | 0.83 | PREP (0.35) | DPP4POLBL3MBTL1FAPDPP7 | |
| SCHEMBL28826381 | 0.83 | DPP4 (0.40) | DPP4POLBL3MBTL1FAPPREP | |
| SCHEMBL29091403 | 0.83 | DPP4 (0.34) | DPP4POLBL3MBTL1FAPDPP7 | |
| SCHEMBL27896393 | 0.80 | GAA (0.43) | ALDH1A1LMNAPOLB | |
| SCHEMBL19104795 | 0.80 | SMN1; SMN2 (0.44) | DPP4POLBL3MBTL1FAPDPP7 | |
| SCHEMBL28801602 | 0.80 | PREP (0.42) | DPP4FAPDPP7PREP | |
| SCHEMBL27879636 | 0.77 | CHRM2 (0.37) | DPP4FAPPREPDPP8DPP9 | |
| SCHEMBL7408815 | 0.77 | POLB (0.36) | DPP4POLBL3MBTL1 | |
| SCHEMBL29091404 | 0.77 | DPP4 (0.33) | DPP4POLBL3MBTL1FAPDPP7 | |
| SCHEMBL27896408 | 0.75 | MC4R (0.48) | ALDH1A1DPP4POLBL3MBTL1PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230503-A | Method for synthesizing vildagliptin by one-pot method | 山东安舜制药有限公司 | 2022-03-25 | — | — | CN | claimed |
| CN-102491928-A | Method for preparing (2S)-N-chloracetyl-2-cyano-group pyrrolidine | LINHAI TIANYU PHARMACEUTICAL CO LTD | 2012-06-13 | — | — | CN | claimed |
| CN-114230503-A | Method for synthesizing vildagliptin by one-pot method | 山东安舜制药有限公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-110642769-B | Preparation method of vildagliptin | 烟台万润药业有限公司 | 2022-03-25 | — | — | CN | disclosed |
| CN-110563627-B | Preparation method of (S) -1- (2-chloroacetyl) pyrrolidine-2-carbonitrile | 沧州那瑞化学科技有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-107098842-B | Purification method of vildagliptin | 南京优科制药有限公司 | 2020-05-08 | — | — | CN | disclosed |
| CN-110642769-A | Preparation method of vildagliptin | 烟台万润药业有限公司 | 2020-01-03 | — | — | CN | disclosed |
| CN-110563627-A | Preparation method of (S) -1- (2-chloroacetyl) pyrrolidine-2-carbonitrile | 沧州那瑞化学科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-103848770-A | Method for preparing midbody (2S)-N-chloracetyl-2-cyano tetrahydropyrrole of vildagliptin | CHENGDU NUOWEIER BIOLOG PHARMACEUTICAL CO LTD | 2014-06-11 | — | — | CN | disclosed |
| CN-103351320-A | Preparation method of (S)-1-(2-chloroacetyl)-pyrrolidine-2-formamide | ZHANGJIAGANG WEISHENG BIOLOG PHARCEUTICAL CO LTD | 2013-10-16 | — | — | CN | disclosed |
| CN-103351320-A | Preparation method of (S)-1-(2-chloroacetyl)-pyrrolidine-2-formamide | ZHANGJIAGANG WEISHENG BIOLOG PHARCEUTICAL CO LTD | 2013-10-16 | — | — | CN | disclosed |
| CN-102491928-A | Method for preparing (2S)-N-chloracetyl-2-cyano-group pyrrolidine | LINHAI TIANYU PHARMACEUTICAL CO LTD | 2012-06-13 | — | — | CN | disclosed |