Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186482 | 0.83 | BDKRB1 (0.42) | BDKRB1TSHRKDM4EHSD17B10HCAR2 | |
| SCHEMBL2786986 | 0.80 | BDKRB1 (0.38) | BDKRB1TSHRKDM4EHSD17B10HCAR2 | |
| SCHEMBL185748 | 0.75 | VNN1 (0.41) | BDKRB1HCAR2VNN1ABL1BACE1 | |
| SCHEMBL20069112 | 0.75 | BDKRB1 (0.38) | BDKRB1HCAR2VNN1HDAC3HDAC1 | |
| SCHEMBL2787773 | 0.75 | VNN1 (0.41) | BDKRB1HCAR2VNN1ABL1BACE1 | |
| SCHEMBL20205895 | 0.72 | BDKRB1 (0.36) | BDKRB1HCAR2VNN1HDAC3HDAC1 | |
| SCHEMBL20147619 | 0.72 | BDKRB1 (0.41) | BDKRB1HCAR2VNN1HDAC3HDAC1 | |
| SCHEMBL20158441 | 0.70 | BDKRB1 (0.39) | BDKRB1VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL27363077 | 0.69 | HCAR2 (0.38) | BDKRB1KDM4EHCAR2ABL1BCAT2 | |
| SCHEMBL185415 | 0.68 | BDKRB1 (0.47) | BDKRB1TSHRKDM4EHSD17B10HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097374-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |