Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.37 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27863055 | 0.87 | AKR1C2 (0.44) | PTPN1PTPN2PTPN6LTB4R2EZH2 | |
| SCHEMBL27879331 | 0.84 | PTGS1 (0.56) | LTB4R2EZH2PTGS1ALDH1A1MAPT | |
| SCHEMBL27879325 | 0.83 | AKR1C2 (0.43) | PTPN1PTPN2PTPN6LTB4R2AKR1C2 | |
| SCHEMBL27879330 | 0.81 | BACE1 (0.36) | PTPN1EZH2PTGS1ALDH1A1MAPT | |
| SCHEMBL27985131 | 0.75 | AKR1C2 (0.43) | PTPN1PTPN2PTPN6LTB4R2EZH2 | |
| SCHEMBL27786187 | 0.73 | PTPN1 (0.58) | PTPN1PTPN2PTPN6AKR1C2AKR1C1 | |
| SCHEMBL27863063 | 0.72 | AKR1C2 (0.46) | PTPN1PTPN2PTPN6AKR1C2AKR1C1 | |
| SCHEMBL18765958 | 0.69 | ALDH1A1 (0.66) | LTB4R2ALDH1A1KDM4EGLATSHR | |
| SCHEMBL14784538 | 0.69 | PTPN1 (0.53) | PTPN1PTPN2PTPN6AKR1C2AKR1C1 | |
| SCHEMBL27802682 | 0.69 | PTPN1 (0.46) | PTPN1PTPN2PTPN6AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574778-A | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2012-07-11 | — | — | CN | claimed |
| CN-102574778-A | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2012-07-11 | — | — | CN | disclosed |