Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GGT1 | P19440 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27863065 | 0.84 | BACE1 (0.39) | BACE1PTGS1MAPTTDP1LMNA | |
| SCHEMBL27863064 | 0.81 | PTPN1 (0.43) | EZH2PTGS1MAPTPTPN1KDM4E | |
| SCHEMBL27879331 | 0.80 | PTGS1 (0.56) | EZH2PTGS1MAPTLMNAGAA | |
| SCHEMBL27879328 | 0.71 | ADORA1 (0.43) | BACE1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL27769325 | 0.70 | TDP1 (0.44) | BACE1PTGS1MAPTTDP1LMNA | |
| SCHEMBL27769336 | 0.70 | TDP1 (0.44) | BACE1PTGS1MAPTTDP1LMNA | |
| SCHEMBL27863055 | 0.70 | AKR1C2 (0.44) | EZH2PTGS1MAPTPTPN1KDM4E | |
| SCHEMBL28796445 | 0.68 | BACE1 (0.42) | BACE1PTGS1MAPTTDP1LMNA | |
| SCHEMBL11531 | 0.67 | LMNA (0.52) | MAPTLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL28794193 | 0.67 | HDAC1 (0.41) | BACE1PTGS1MAPTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574778-A | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2012-07-11 | — | — | CN | disclosed |