Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27863129 | 0.84 | EGFR (0.38) | HTTPOLBKMT2AFBP1 | |
| SCHEMBL4417636 | 0.81 | NR4A2 (0.47) | HTTRXFP1SMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL16061044 | 0.80 | NR4A2 (0.46) | HTTRXFP1SMN1; SMN2ALDH1A1KDM4E | |
| Ethoxycarbonyl Group SCHEMBL27607080 | 0.78 | PARP1 (0.37) | ALDH1A1KDM4EHPGD | |
| Ethoxycarbonyl Group SCHEMBL27845978 | 0.74 | ENPP1 (0.43) | HTTSMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| Ethoxycarbonyl Group SCHEMBL28094497 | 0.72 | ENPP1 (0.47) | HTTSMN1; SMN2ALDH1A1KDM4EPOLB | |
| 1,4-Dichlorobenzene SCHEMBL27842897 | 0.71 | HSD17B10 (0.42) | HTTSMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| Ethoxycarbonyl Group SCHEMBL27729020 | 0.70 | PYGL (0.43) | KMT2ANPC1RAB9AATMCYP1A2 | |
| Ethoxycarbonyl Group SCHEMBL27845970 | 0.70 | PDE4A (0.62) | HTTSMN1; SMN2ALDH1A1NPSR1POLB | |
| Ethoxycarbonyl Group SCHEMBL27863139 | 0.69 | KDM4E (0.39) | ALDH1A1KDM4EPOLBKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837560-A | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | 埃姆比特生物科学公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-105601619-A | JAK kinase modulating compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2016-05-25 | — | — | CN | disclosed |
| CN-102395576-A | Quinazoline derivatives that modulate JAK kinases and methods of use thereof | AMBIT BIOSCIENCES CORP | 2012-03-28 | — | — | CN | disclosed |