Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16061044 | 0.98 | NR4A2 (0.46) | NR4A2SOS2CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL3734931 | 0.84 | HTT (0.49) | NR4A2CYP1A2CYP2D6ALDH1A1MAPT | |
| Ethoxycarbonyl Group SCHEMBL27863232 | 0.81 | HTT (0.39) | CYP1A2CYP2D6ALDH1A1ATMKDM4E | |
| SCHEMBL29416410 | 0.79 | PDE4A (0.57) | NR4A2SOS2CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL401110 | 0.79 | PDE4A (0.57) | NR4A2SOS2CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL5453911 | 0.79 | EGFR (0.46) | ALDH1A1MAPTKDM4EHPGDHTT | |
| Hydrochloric Acid SCHEMBL5739823 | 0.78 | PDE4A (0.55) | NR4A2SOS2CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL2082154 | 0.76 | EGFR (0.51) | HTTLMNAKMT2AMEN1 | |
| SCHEMBL13702434 | 0.76 | EGFR (0.32) | — | |
| SCHEMBL6442231 | 0.76 | NR4A2 (0.56) | NR4A2SOS2CYP1A2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117209436-A | Preparation method of dacatinib key intermediate | 江苏海洋大学 | 2023-12-12 | — | — | CN | disclosed |
| CN-111116552-B | Quinazolinone compound and preparation method thereof | 河北科技大学 | 2022-10-11 | — | — | CN | disclosed |
| CN-111116552-A | Quinazolinone compound and preparation method thereof | 河北科技大学 | 2020-05-08 | — | — | CN | disclosed |
| CN-104774184-A | Alpha-cyano-alpha, beta-unsaturated amide compound and medical application thereof | UNIV CHINA PHARMA | 2015-07-15 | — | — | CN | disclosed |
| CN-102838550-B | Quinolinylcrotyl compound and its application in preparation of anti-malignant tumor drugs | METABOMICS INC. (CN) | 2014-10-01 | — | — | CN | disclosed |
| WO-2014145512-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |
| CN-101899011-B | Dithiocarbamates compound, preparation method and application thereof | UNIV BEIJING | 2013-01-16 | — | — | CN | disclosed |
| CN-102838550-A | Quinolinylcrotyl compound and its application in preparation of anti-malignant tumor drugs | SUZHOU METABOMICS INC | 2012-12-26 | — | — | CN | disclosed |
| CN-101899011-A | Dithiocarbamates compound, preparation method and application thereof | UNIV BEIJING | 2010-12-01 | — | — | CN | disclosed |
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-2098508-A1 | Cyclic derivatives as modulators of chemokine receptor activity | Bristol-Myers Squibb Company (US) | 2009-09-09 | — | — | EP | disclosed |
| US-20080114052-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY | 2008-05-15 | — | — | US | disclosed |
| US-7338947-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB CO. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7183270-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-27 | — | — | US | disclosed |
| US-20070032541-A1 | Cyclic derivatives as modulators of chemokine receptor activity | CHERNEY ROBERT J | 2007-02-08 | — | — | US | disclosed |
| EP-1606255-A4 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1606255-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20040186140-A1 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2004-09-23 | — | — | US | disclosed |
| WO-2004071460-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114052-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | CCL11, CCL2, CCR1 | NR4A2 1241/4885SOS2 3504/4885CYP1A2 3221/4885 |
| US-20040186140-A1 | Cyclic derivatives as modulators of chemokine receptor activity | CCL11, CCR1, CCL2 | NR4A2 1237/4885SOS2 3514/4885CYP1A2 3163/4885 |
| US-20070032541-A1 | Cyclic derivatives as modulators of chemokine receptor activity | CCL11, CCL2, CCR1 | NR4A2 1241/4885SOS2 3504/4885CYP1A2 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.