Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28140151 | 0.89 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28092397 | 0.86 | ADRA2A (0.36) | ADRA2AADRA2BADRA2C | |
| SCHEMBL28126370 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL27786102 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28133212 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28197359 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28159355 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL27805312 | 0.84 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28123487 | 0.84 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28148564 | 0.83 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105339351-B | Arginine methyltransferase inhibitors and uses thereof | EPIZYME股份有限公司 | 2018-11-06 | — | — | CN | disclosed |
| CN-104870449-B | Compound (I) | 奇斯药制品公司 | 2018-11-06 | — | — | CN | disclosed |
| CN-108602778-A | 8-amino-2-oxo-1, 3-diaza-spiro- [4.5] -decane derivatives | 格吕伦塔尔有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-108290856-A | Aryl-substituted dihydroquinolones, their preparation and their use as medicaments | 尼奥迈德研究所 | 2018-07-17 | — | — | CN | disclosed |
| CN-107848974-A | Aromatic sulfonamide derivatives | 拜耳制药股份公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107438607-A | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | 因赛特公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-107207507-A | 1, 3-thiazol-2-yl substituted benzamides | 拜耳公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105073741-B | Phthalazinones and isoquinolinones as ROCK inhibitors | 百时美施贵宝公司 | 2017-08-08 | — | — | CN | disclosed |
| CN-107027306-A | 1 (ring penta 2 base of alkene 1) 3 (2 hydroxyl 3 (aryl sulfonyl) phenyl) urea derivatives are used as CXCR2 inhibitor | 葛兰素史密斯克莱知识产权发展有限公司 | 2017-08-08 | — | — | CN | disclosed |
| CN-107001309-A | Double (sulfonamide) derivatives and its purposes as MPGES inhibitor | 埃克杜鲁姆房地产有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-107001316-A | It is used as the Carbostyril derivative of antiseptic | 诺华股份有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-106928247-A | Spiral shell oxindole compounds and its purposes as therapeutic agent | 泽农医药公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-106795156-A | 2- (morpholin-4-yl) -1, 7-naphthyridine | 拜耳制药股份公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106715438-A | Triazolopyrazinones as PDE1 inhibitors | H.隆德贝克有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-106604920-A | Pyridone derivatives with tetrahydropyranylmethyl groups | 第三共株式会社 | 2017-04-26 | — | — | CN | disclosed |
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-102596913-A | Cannabinoid receptor modulators | ARENA PHARM INC | 2012-07-18 | — | — | CN | disclosed |