Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28123487 | 0.90 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28126370 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL27865360 | 0.86 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL27786102 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28197359 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28133212 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL27805312 | 0.84 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28148564 | 0.83 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28140151 | 0.83 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 | |
| SCHEMBL28129370 | 0.83 | CYP1A2 (0.39) | ADRA2AADRA2BADRA2CHPRT1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008322-B | sulfonamide derivatives as BC L-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-107531728-A | Amino hydrogen thiazine derivative available for the tetrahydrofuran fusion for the treatment of Alzheimer's | 伊莱利利公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-107278203-A | It is used as pyrazolo [1,5 a] pyrazine of 4,6 substitutions of JANUS kinase inhibitors | 阵列生物制药公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-107001281-A | Substituted benzothiophene radical derivative is used as the GPR40 activators for treating type ii diabetes | 詹森药业有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-102307872-B | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-06-15 | — | — | CN | disclosed |