Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27564648 | 0.83 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL17192714 | 0.80 | MAPT (0.50) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL28200178 | 0.80 | MAPT (0.50) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL18630198 | 0.80 | MAPT (0.50) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL5253033 | 0.80 | MAPT (0.50) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL953597 | 0.79 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL28378797 | 0.76 | MAPT (0.57) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL25062056 | 0.75 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL361389 | 0.75 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1IDO1 | |
| SCHEMBL14042535 | 0.75 | MAPT (0.58) | MAPTALDH1A1KMT2AMEN1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459172-B | Tetracyclic compound | CHUGAI PHARMACEUTICAL CO LTD | 2015-06-24 | — | — | CN | disclosed |
| CN-102459172-A | Tetracyclic compounds | CHUGAI PHARMACEUTICAL CO LTD | 2012-05-16 | — | — | CN | disclosed |